2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one
• CAS No.: 338422-68-7
• Molecular Formula: C₁₁H₉F₃N₂O₂
• Molecular Weight: 258.2
• Mol file: 338422-68-7.mol

Synonyms:2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one

Chemical Property of 2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one

There total 1 articles about 2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxyphenylhydrazine hydrochloride (19501-58-7) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one (338422-68-7)

Guidance literature:

With sodium acetate; In acetic acid; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.06.090

Reference yield: 91.0%

2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one (338422-68-7) → 4-diazo-1-(4-methoxyphenyl)-3-trifluoromethylpyrazolin-5-one (1384431-61-1)

Guidance literature:

With 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl azide; triethylamine; In dichloromethane; at -10 - 20 ℃;

DOI:10.1016/j.tet.2012.05.062

Reference yield: 89.0%

2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one (338422-68-7) + 4-methyl-benzaldehyde (104-87-0) + dimedone (126-81-8) → 1-(4-methoxyphenyl)-7,7-dimethyl-4-(p-tolyl)-3-(trifluoromethyl)-4,6,7,8-tetrahydrochromeno[2,3-c]pyrazol-5(1H)-one

Guidance literature:

With toluene-4-sulfonic acid; In chloroform; for 12h; Reflux;

DOI:10.1055/s-0034-1380204

upstream raw materials:

4-methoxyphenylhydrazine hydrochloride

ethyl 4,4,4-trifluoroacetoacetate

Downstream raw materials:

4-diazo-1-(4-methoxyphenyl)-3-trifluoromethylpyrazolin-5-one

dimethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate

diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate