diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate

Base Information

• Chemical Name: diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate
• CAS No.: 1384431-75-7
• Molecular Formula: C₁₉H₁₇F₃N₂O₆
• Molecular Weight: 426.349
• Mol file: 1384431-75-7.mol

Synonyms:diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate

Chemical Property of diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate

There total 2 articles about diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-diazo-1-(4-methoxyphenyl)-3-trifluoromethylpyrazolin-5-one (1384431-61-1) + acetylenedicarboxylic acid diethyl ester (762-21-0) → diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate (1384431-75-7)

Guidance literature:

In 1,2-dichloro-benzene; at 160 ℃; for 7h;

DOI:10.1016/j.tet.2012.05.062

Reference yield:

2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one (338422-68-7) → diethyl 1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole-4,5-dicarboxylate (1384431-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl azide; triethylamine / dichloromethane / -10 - 20 °C

2: 1,2-dichloro-benzene / 7 h / 160 °C

With 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl azide; triethylamine; In dichloromethane; 1,2-dichloro-benzene;

DOI:10.1016/j.tet.2012.05.062

upstream raw materials:

4-diazo-1-(4-methoxyphenyl)-3-trifluoromethylpyrazolin-5-one

acetylenedicarboxylic acid diethyl ester

2-(4-methoxyphenyl)-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one