3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid

Base Information

Chemical Name:3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid
CAS No.:133390-71-3
Molecular Formula:C₁₉H₁₇ClN₂O₃
Molecular Weight:356.809
Hs Code.:

Synonyms:3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid

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Technology Process of 3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid

There total 1 articles about 3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 119600-38-3
6-(4-Methoxyphenyl)-4,6-dioxohexanoic acid

: 133390-71-3
3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid

Guidance literature:: With triethylamine; In methanol; for 6h; Ambient temperature;
DOI:10.1055/s-1991-26367

Reference yield:

: 133390-71-3
3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid

: 3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride

Guidance literature:: With oxalyl dichloride; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1055/s-1991-26367

Reference yield:

: 133390-71-3
3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionic acid

: 114150-43-5
3-[1-(4-Chloro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂ / 3 h / Ambient temperature

2: NEt₃ / CH₂Cl₂ / 1 h / Ambient temperature

With oxalyl dichloride; triethylamine; In dichloromethane;
DOI:10.1055/s-1991-26367