5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione

Base Information

Chemical Name:5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione
CAS No.:168632-28-8
Molecular Formula:C₂₃H₁₈N₂O₅S
Molecular Weight:434.472
Hs Code.:

Synonyms:5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione

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Chemical Property of 5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione

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Technology Process of 5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione

There total 3 articles about 5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-[[2-[(5-Methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl]methylene]-2,4-thiazolidinedione

: 168632-28-8
5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione

Guidance literature:: With sodium amalgam; In tetrahydrofuran; methanol; for 1h;
DOI:10.1021/jm960230h

Reference yield:

: 132672-20-9
5-bromo-α-(5-methyl-2-phenyloxazol-4-yl)-2-benzofuranmethanol

: 168632-28-8
5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, from -78 deg C to RT

2: 58 percent / piperidine / ethanol / Heating

3: 0.46 g / 3percent sodium amalgam / methanol; tetrahydrofuran / 1 h

With piperidine; sodium amalgam; n-butyllithium; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm960230h

Reference yield:

: 147046-94-4
2-[(5-methyl-2-phenyl-4-oxazolyl)-hydroxymethyl]-5-benzofurancarboxaldehyde

: 168632-28-8
5-[[2-[(5-methyl-2-phenyl-4-oxazolyl)hydroxymethyl]benzofuran-5-yl)methyl]-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / piperidine / ethanol / Heating

2: 0.46 g / 3percent sodium amalgam / methanol; tetrahydrofuran / 1 h

With piperidine; sodium amalgam; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm960230h