(R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid

Base Information

Chemical Name:(R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid
CAS No.:1373277-55-4
Molecular Formula:C₃₀H₂₈FN₃O₄
Molecular Weight:513.568
Hs Code.:

Synonyms:(R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid

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Chemical Property of (R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid

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Technology Process of (R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid

There total 20 articles about (R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373278-84-2
5-(3-(4-fluorophenyl)-7-((S)-5-((S)-hydroxy(phenyl)methyl)-5-methyl-4,5-dihydroisoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid

: 1373277-55-4
(R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: With phosphorus; iodine; acetic acid; In water; at 20 ℃; for 3h; sealed tube;

Reference yield:

: 4383-08-8,103729-80-2,147127-68-2,116297-42-8
(S)-(+)-2-methyl-1-phenyl-2-propen-1-ol

: 1373277-55-4
(R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hypochlorite / 20 °C

2: trifluoroacetic acid / 3 h / 20 °C

3: iodine; phosphorus; acetic acid / water / 3 h / 20 °C / sealed tube

With phosphorus; sodium hypochlorite; iodine; acetic acid; trifluoroacetic acid; In water;

Reference yield:

: 1373278-83-1
tert-butyl 5-(3-(4-fluorophenyl)-7-((S)-5-((S)-hydroxy(phenyl)methyl)-5-methyl-4,5-dihydroisoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373277-55-4
(R)-5-(7-(5-benzyl-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 3 h / 20 °C

2: iodine; phosphorus; acetic acid / water / 3 h / 20 °C / sealed tube

With phosphorus; iodine; acetic acid; trifluoroacetic acid; In water;