(1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol

Base Information

Chemical Name:(1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol
CAS No.:768402-54-6
Molecular Formula:C₂₂H₂₇O₂P
Molecular Weight:354.429
Hs Code.:

Synonyms:(1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol

Suppliers and Price of (1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol

There total 4 articles about (1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13292-87-0
dimethylsulfide borane complex

: 869290-47-1
[[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl]diphenylphosphine oxide

: 768402-54-6
(1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol

Guidance literature:: dimethylsulfide borane complex; [[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl]diphenylphosphine oxide; at 50 ℃; for 6h;

With methanol; for 4h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 15 ℃; for 1h; Cooling with acetone-dry ice;

Reference yield:

: 869290-47-1
[[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl]diphenylphosphine oxide

: 768402-54-6
(1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol

Guidance literature:: [[(1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl]diphenylphosphine oxide; With dimethylsulfide borane complex; In toluene; at 50 ℃; for 6h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 10 - 15 ℃;
DOI:10.1016/j.tetasy.2004.05.045

Reference yield:

: 19894-98-5
6,6-dimethyl-2-methylene-bicyclo[3.1.1]heptan-3-ol

: 768402-54-6
(1S,2R,3S,5R)-2-[(diphenylphosphinoyl)methyl]-6,6-dimethylbicyclo[3.1.1]heptan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-(dimethylamino)pyridine / toluene / 6 h / 80 °C

2.1: borane-dimethyl sulfide complex / toluene / 6 h / 50 °C

2.2: 18.4 g / meta-chloroperbenzoic acid / CH₂Cl₂ / 10 - 15 °C

With dmap; dimethylsulfide borane complex; In toluene;
DOI:10.1016/j.tetasy.2004.05.045