4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

Base Information

Chemical Name:4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester
CAS No.:217462-63-0
Molecular Formula:C₃₂H₃₃IO₄Si
Molecular Weight:636.602
Hs Code.:

Synonyms:4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

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Chemical Property of 4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

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Technology Process of 4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

There total 8 articles about 4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-07-2
4-methoxy-benzoyl chloride

: 217462-60-7
[4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-phenyl]-methanol

: 217462-63-0
4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

Guidance literature:: With pyridine; dmap; triethylamine; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1055/s-1998-1900

Reference yield:

: 6232-88-8
4-bromomethylbenzoic Acid

: 217462-63-0
4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 83 percent / HNO₃, H₂O / 3 h / -10 °C

2: 91 percent / Na₂CO₃, H₂O / acetone / 12 h / Heating

3: 83 percent / BF₃*OEt₂ / 15 h / Heating

4: 95 percent / DMAP, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 75 percent / Na₂S₂O₄, H₂O / ethanol / 0.5 h / 100 °C

6: 80 percent / iAmONO, I₂ / benzene / 100 °C

7: 95 percent / DIBAH / toluene / 3 h / Ambient temperature

8: 96 percent / pyridine, Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

With pyridine; dmap; sodium dithionite; boron trifluoride diethyl etherate; water; iodine; nitric acid; diisobutylaluminium hydride; sodium carbonate; triethylamine; isopentyl nitrite; In ethanol; dichloromethane; acetone; toluene; benzene;
DOI:10.1055/s-1998-1900

Reference yield:

: 55715-03-2
4-bromomethyl-3-nitrobenzoic acid

: 217462-63-0
4-Methoxy-benzoic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-3-iodo-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / Na₂CO₃, H₂O / acetone / 12 h / Heating

2: 83 percent / BF₃*OEt₂ / 15 h / Heating

3: 95 percent / DMAP, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 75 percent / Na₂S₂O₄, H₂O / ethanol / 0.5 h / 100 °C

5: 80 percent / iAmONO, I₂ / benzene / 100 °C

6: 95 percent / DIBAH / toluene / 3 h / Ambient temperature

7: 96 percent / pyridine, Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

With pyridine; dmap; sodium dithionite; boron trifluoride diethyl etherate; water; iodine; diisobutylaluminium hydride; sodium carbonate; triethylamine; isopentyl nitrite; In ethanol; dichloromethane; acetone; toluene; benzene;
DOI:10.1055/s-1998-1900