ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate

Base Information

Chemical Name:ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate
CAS No.:1352933-77-7
Molecular Formula:C₂₂H₁₉F₃N₂O₄
Molecular Weight:432.399
Hs Code.:

Synonyms:ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate

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Chemical Property of ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate

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Technology Process of ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate

There total 4 articles about ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352933-76-6
benzyl (6-(trifluoromethyl)quinolin-4-yl)carbamate

: 105-36-2
ethyl bromoacetate

: 1352933-77-7
ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate

Guidance literature:: benzyl (6-(trifluoromethyl)quinolin-4-yl)carbamate; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1352933-76-6
benzyl (6-(trifluoromethyl)quinolin-4-yl)carbamate

: 96-32-2
bromoacetic acid methyl ester

: 1352933-77-7
ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2012.12.017

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1352933-77-7
ethyl 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 20 °C

With sodium hydrogencarbonate; caesium carbonate; In water; ethyl acetate; N,N-dimethyl-formamide;