4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one

Base Information

Chemical Name:4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one
CAS No.:1428554-07-7
Molecular Formula:C₂₉H₂₉NO₄
Molecular Weight:455.554
Hs Code.:

Synonyms:4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one

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Chemical Property of 4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one

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Technology Process of 4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one

There total 5 articles about 4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 110-91-8,99108-56-2
morpholine

: 6-bromo-5,7-dimethyl-4-(4-methoxyphenyl)coumarin

: 68162-47-0
4-bromomethylphenylboronic acid

: 1428554-07-7
4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2013.09.035

Reference yield:

: 696-62-8
para-iodoanisole

: 1428554-07-7
4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 12.5 h / -78 - 20 °C

2.1: formic acid / 1 h / 40 °C

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 0 - 20 °C

4.1: palladium diacetate; trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 0.5 h / 120 °C

With dmap; formic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1.2: |Sonogashira Cross-Coupling / 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.09.035

Reference yield:

: 2227-57-8
3-(4-methoxyphenyl)propynoic acid

: 1428554-07-7
4-(4-methoxyphenyl)-5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 h / 0 - 20 °C

2: palladium diacetate; trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 0.5 h / 120 °C

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.09.035