(+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Base Information

Chemical Name:(+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol
CAS No.:107208-17-3
Molecular Formula:C₁₃H₂₂O₃
Molecular Weight:226.316
Hs Code.:

Synonyms:(+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Suppliers and Price of (+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

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Chemical Property of (+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Chemical Property:

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Technology Process of (+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

There total 3 articles about (+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 107208-16-2
2,6-Dimethyl-1-[3-(tetrahydro-pyran-2-yloxy)-but-1-ynyl]-2-(tetrahydro-pyran-2-yloxymethyl)-cyclohexanol

: 107208-17-3
(+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Guidance literature:: pyridinium p-toluenesulfonate; In ethanol; at 55 ℃; for 4.5h;

Reference yield:

: 13756-98-4
(+/-)-2-hydroxymethyl-2,6-dimethyl-1-cyclohexanone

: 107208-17-3
(+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH / benzene / 3.5 h / Ambient temperature

2: 93 percent / n-BuLi / tetrahydrofuran; hexane / -10 - 0 deg C, 2 h. then room temp.

3: 98 percent / PPTS / ethanol / 4.5 h / 55 °C

With n-butyllithium; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; hexane; benzene;

Reference yield:

: 107208-15-1
(+/-)-2,6-dimethyl-2-tetrahydropyranyl-oxymethyl-1-cyclohexanone

: 107208-17-3
(+/-)-4-(1'-hydroxy-2'-hydroxymethyl-2',6'-dimethylcyclohexyl)-but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / n-BuLi / tetrahydrofuran; hexane / -10 - 0 deg C, 2 h. then room temp.

2: 98 percent / PPTS / ethanol / 4.5 h / 55 °C

With n-butyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; ethanol; hexane;