Technology Process of (2Z,4E)-methoxymethyl 19-((tert-butyldiphenylsilyl)oxy)-3-(2-hydroxyethyl)nonadeca-2,4-dienoate
There total 10 articles about (2Z,4E)-methoxymethyl 19-((tert-butyldiphenylsilyl)oxy)-3-(2-hydroxyethyl)nonadeca-2,4-dienoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; triethylamine;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 40h;
DOI:10.1021/tx300315h
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.33 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 - 20 °C / Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
2.2: 0.17 h / 0 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C
4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.33 h / -78 °C / Inert atmosphere
4.2: 0.5 h / -78 - 20 °C / Inert atmosphere
5.1: chloro-trimethyl-silane; chromium dichloride; lithium iodide; manganese / tetrahydrofuran / 16.5 h / 20 °C / Inert atmosphere
6.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; methanol / 40 h / 20 °C
With
chromium dichloride; bis-triphenylphosphine-palladium(II) chloride; manganese; n-butyllithium; chloro-trimethyl-silane; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; dimethyl sulfoxide; triethylamine; lithium iodide;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
6.1: |Suzuki Coupling;
DOI:10.1021/tx300315h
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen bromide / toluene
2.1: triphenylphosphine / acetonitrile / 90 h / Reflux
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
3.2: 0.17 h / 0 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C
5.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.33 h / -78 °C / Inert atmosphere
5.2: 0.5 h / -78 - 20 °C / Inert atmosphere
6.1: chloro-trimethyl-silane; chromium dichloride; lithium iodide; manganese / tetrahydrofuran / 16.5 h / 20 °C / Inert atmosphere
7.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; methanol / 40 h / 20 °C
With
chromium dichloride; bis-triphenylphosphine-palladium(II) chloride; manganese; n-butyllithium; chloro-trimethyl-silane; oxalyl dichloride; palladium 10% on activated carbon; hydrogen bromide; hydrogen; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium iodide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile;
7.1: |Suzuki Coupling;
DOI:10.1021/tx300315h
