2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid

Base Information

• Chemical Name: 2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid
• CAS No.: 1313196-01-8
• Molecular Formula: C₁₇H₁₁F₃O₂S
• Molecular Weight: 336.334
• Mol file: 1313196-01-8.mol

Synonyms:2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid

Chemical Property of 2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid

There total 2 articles about 2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carbonitrile (1313195-99-1) → 2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid (1313196-01-8)

Guidance literature:

2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carbonitrile; With water; sodium hydroxide; In ethanol; at 80 ℃; for 15h;

With hydrogenchloride; In ethanol; water;

Reference yield:

7-bromo-2-[3-(trifluoromethyl)benzyl]-1-benzothiophene (1207970-72-6) → 2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid (1313196-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 8 h / 150 °C

2: sodium hydroxide; water / ethanol / 15 h / 80 °C

With water; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield: 93.0%

2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid (1313196-01-8) → 2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxamide (1313196-00-7)

Guidance literature:

2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 1h;

With ammonia; In water; N,N-dimethyl-formamide; at 10 - 35 ℃; for 1h;

upstream raw materials:

7-bromo-2-[3-(trifluoromethyl)benzyl]-1-benzothiophene

2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carbonitrile

Downstream raw materials:

ethyl 4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxylate

N-(2-methoxyethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carboxamide