N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

Base Information

Chemical Name:N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide
CAS No.:1313196-89-2
Molecular Formula:C₂₃H₁₈F₃N₃O₃S
Molecular Weight:473.475
Hs Code.:

Synonyms:N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

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Chemical Property of N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

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Technology Process of N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

There total 5 articles about N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₄F₃NO₃S

: 1668-10-6
glycinamide hydrochloride

: 1313196-89-2
N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 1207970-72-6
7-bromo-2-[3-(trifluoromethyl)benzyl]-1-benzothiophene

: 1313196-89-2
N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide / 8 h / 150 °C

2.1: sodium hydroxide; water / ethanol / 15 h / 80 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 10 - 35 °C

3.2: 1 h / 10 - 35 °C

4.1: 7 h / 120 °C

5.1: sodium hydroxide; water / ethanol / 1 h / 50 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1313195-99-1
2-[3-(trifluoromethyl)benzyl]-1-benzothiophene-7-carbonitrile

: 1313196-89-2
N-(2-amino-2-oxoethyl)-4-methyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3-oxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / ethanol / 15 h / 80 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 10 - 35 °C

2.2: 1 h / 10 - 35 °C

3.1: 7 h / 120 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 50 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;