Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester
• CAS No.: 350580-88-0
• Molecular Formula: C₃₃H₅₇NO₈SSi₂
• Molecular Weight: 684.054

Synonyms:Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

Chemical Property of Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

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MSDS Files:

SDS file from LookChem

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Technology Process of Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester

There total 3 articles about Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

[2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene (350580-97-1) + Methanesulfonic anhydride (7143-01-3) → Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester (350580-88-0)

Guidance literature:

With pyridine;

DOI:10.1021/jo0101510

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester (350580-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0 - 20 °C

2: 75 percent / pyridine

With pyridine;

DOI:10.1021/jo0101510

Reference yield:

[2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(RS)-(1,2-dihydroxyethyl)-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]inde → Methanesulfonic acid (S)-2-(tert-butyl-dimethyl-silanyloxy)-1-[(2aS,3R,6R,7aS,7bR)-2,2-diisopropyl-6-((1S,2R)-2-phenyl-cyclohexyloxy)-hexahydro-1,4,5-trioxa-4a-aza-2-sila-cyclopenta[cd]inden-3-yl]-ethyl ester (350580-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0 - 20 °C

2: 75 percent / pyridine

With pyridine;

DOI:10.1021/jo0101510

upstream raw materials:

[2aS,3R(1S),6R(1S,2R),7aS,7bR]-hexahydro-2,2-bis(1-methylethyl)-3-(S)-[2-[((1,1-dimethylethyl)dimethylsilyl)oxy]-1-hydroxyethyl]-6-[(2-phenylcyclohexyl)oxy]-2H-1,4,5-trioxy-4a-aza-2-silacyclopent[cd]indene

Methanesulfonic anhydride

t-butyldimethylsiyl triflate

Downstream raw materials:

(1S,2R)-trans-2-phenyl-1-cyclohexanol

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