2,3-Diphenyl-1H-inden-1-one

Base Information

• Chemical Name: 2,3-Diphenyl-1H-inden-1-one
• CAS No.: 1801-42-9
• Molecular Formula: C21H14 O
• Molecular Weight: 282.342
• Hs Code.: 29143900
• European Community (EC) Number: 217-290-1
• NSC Number: 401880,60783
• UNII: H3L707J8Y8
• DSSTox Substance ID: DTXSID90939299
• Nikkaji Number: J109.811J
• Wikidata: Q27115928
• ChEMBL ID: CHEMBL69829
• Mol file: 1801-42-9.mol

Synonyms:2,3-diphenyl-1-indanone

Chemical Property of 2,3-Diphenyl-1H-inden-1-one

Chemical Property:

• Vapor Pressure: 3.01E-08mmHg at 25°C
• Melting Point: 153-154 °C(lit.)
• Refractive Index: 1.4880 (estimate)
• Boiling Point: 448.8°Cat760mmHg
• Flash Point: 197.9°C
• PSA: 17.07000
• Density: 1.213g/cm³
• LogP: 4.84200
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 282.104465066
• Heavy Atom Count: 22
• Complexity: 449

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Diphenyl-1-indenone 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C(=O)C3=CC=CC=C32)C4=CC=CC=C4

Technology Process of 2,3-Diphenyl-1H-inden-1-one

There total 174 articles about 2,3-Diphenyl-1H-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methyl 2,3,3-triphenylacrylate (181224-77-1) → 2,3-diphenyl-1H-inden-1-one (1801-42-9)

Guidance literature:

With methanesulfonic acid; In dichloromethane; at 20 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01693

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + bromo-triphenyl-methane (596-43-0) → 2,3-diphenyl-1H-inden-1-one (1801-42-9) + but-1-ene-1,1,2-triyltribenzene (63019-13-6)

Guidance literature:

With copper(II) sulfate;

Reference yield:

2,3-diphenyl-1H-indene (5324-00-5) → 2,3-diphenyl-1H-inden-1-one (1801-42-9) + 1,2-diphenyl-inden-1-yl hydroperoxide (102242-24-0)

Guidance literature:

With pyridine; benzyl-triphenyl-ammonium hydroxide; oxygen;

DOI:10.1021/ja01553a033

upstream raw materials:

diazoacetic acid ethyl ester

bromo-triphenyl-methane

2,3-diphenyl-1H-indene

phenindione

Downstream raw materials:

2,3-diphenyl-1-methyl-1H-inden-1-ol

1-ethyl-2,3-diphenyl-1H-inden-1-ol

2,3-diphenyl-1H-indene

2,3-diphenyl-indan-1-one

Refernces

• 1、 Zhao, Peng,Liu, Yu,Xi, Chanjuan. "MeOTf-Induced Carboannulation of Isothiocyanates and Aryl Alkynes with C=S Bond Cleavage: Access to Indenones". . p. 4388 - 4391. Retrieved 2015.
• 2、 Larock, Richard C.,Tian, Qingping,Pletnev, Alexandre A.. "Carbocycle synthesis via carbopalladation of nitriles [11]". . p. 3238 - 3239. Retrieved 1999.
• 3、 Kolobova,Goncharenko. "". . . Retrieved 1979.
• 4、 Marsili,Isola. "". . p. 3023,3025. Retrieved 1965.
• 5、 Xu, Yao-Chang,Wulff, William D.. "Alkylations of Tetracarbonyl(phosphine)chromium and Pentacarbonylchromium Carbene Complexes and Their Reactions with Selected Acetylenes". . p. 3263 - 3275. Retrieved 1987.
• 6、 Li, Liang,Wang, Guan-Wu. "Mechanochemical Solvent-Free Synthesis of Indenones from Aromatic Carboxylic Acids and Alkynes". . p. 14102 - 14112. Retrieved 2021/09/07.
• 7、 Jafarpour, Farnaz,Azizzade, Meysam,Golpazir-Sorkheh, Yekta,Navid, Hamed,Rajai-Daryasarei, Saideh. "Divergent Synthesis of α-Aroyloxy Ketones and Indenones: A Controlled Domino Radical Reaction for Di- A nd Trifunctionalization of Alkynes". . p. 8287 - 8294. Retrieved 2020/07/15.