methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate

Base Information

Chemical Name:methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate
CAS No.:1301660-71-8
Molecular Formula:C₂₇H₂₃F₇N₂O₃
Molecular Weight:556.48
Hs Code.:

Synonyms:methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate

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Chemical Property of methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate

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Technology Process of methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate

There total 2 articles about methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-71-8
methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / Reflux

With hydrogenchloride; osmium(VIII) oxide; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-54-7
2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-ethenyl-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-N,2-dimethylpropanamide

: 1301660-71-8
methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / Reflux

With hydrogenchloride; osmium(VIII) oxide; water; In tetrahydrofuran;