methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester

Base Information

• Chemical Name: methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester
• CAS No.: 332841-51-7
• Molecular Formula: C₂₉H₂₉NO₇S
• Molecular Weight: 535.618
• Mol file: 332841-51-7.mol

Synonyms:methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester

Chemical Property of methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester

There total 3 articles about methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride (5884-22-0) + o-mesyloxyphenacyl bromide (332841-50-6) → methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester (332841-51-7)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1016/S0040-4039(00)02222-X

Reference yield:

2-acetylphenyl methanesulfonate (99179-74-5) → methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester (332841-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / benzyltrimethylammonium tribromide / CH₂Cl₂

2: 63 percent / K₂CO₃ / acetonitrile / Heating

With benzyltrimethylammonium tribromide; potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)02222-X

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester (332841-51-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / Et₃N / CH₂Cl₂

2: 81 percent / benzyltrimethylammonium tribromide / CH₂Cl₂

3: 63 percent / K₂CO₃ / acetonitrile / Heating

With benzyltrimethylammonium tribromide; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)02222-X

upstream raw materials:

1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride

o-mesyloxyphenacyl bromide

2-acetylphenyl methanesulfonate

o-hydroxyacetophenone

Downstream raw materials:

1-(3,4-dimethoxy-phenyl)-2-(2-hydroxy-phenyl)-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinoline-3-carbaldehyde

methanesulfonic acid 2-[1-(3,4-dimethoxy-phenyl)-3-formyl-8,9-dimethoxy-5,6-dihydro-pyrrolo[2,1-a]isoquinolin-2-yl]-phenyl ester