2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester
CAS No.:136284-55-4
Molecular Formula:C₂₈H₂₈N₆O₂
Molecular Weight:480.569
Hs Code.:

Synonyms:2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

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Chemical Property of 2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

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Technology Process of 2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

There total 7 articles about 2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 136285-56-8
methyl 2-butyl-1-(2'-cyanobiphenyl-4-yl)methyl-5-methylbenzimidazole-7-carboxylate

: 136284-55-4
2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 110 - 120 ℃; for 84h;
DOI:10.1021/jm00064a011

Reference yield:

: 18595-16-9
2-amino-5-methylbenzoic acid methyl ester

: 136284-55-4
2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / triethylamine / CHCl₃ / 4 h / 0 °C

2: 61 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature

3: 82 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

4: 100 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating

5: 12 percent / NaN₃, NH₄Cl / dimethylformamide / 84 h / 110 - 120 °C

With hydrogenchloride; sodium azide; sulfuric acid; nitric acid; acetic anhydride; iron; potassium carbonate; ammonium chloride; triethylamine; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 136284-55-4
2-Butyl-6-methyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 15 h / Ambient temperature

2: 100 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating

3: 12 percent / NaN₃, NH₄Cl / dimethylformamide / 84 h / 110 - 120 °C

With hydrogenchloride; sodium azide; iron; potassium carbonate; ammonium chloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011