Technology Process of (R)-(+)-3-(3-bromopropyl)-2,2-diphenyloxirane
There total 6 articles about (R)-(+)-3-(3-bromopropyl)-2,2-diphenyloxirane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Oxone; Shi's ketone; borax; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate;
In
acetonitrile;
at -5 ℃;
for 4h;
enantioselective reaction;
DOI:10.1021/jo400648f
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene / 3 h / 70 °C
2: Shi's ketone; borax; tetra(n-butyl)ammonium hydrogensulfate; Oxone; potassium carbonate / acetonitrile / 4 h / -5 °C
With
Oxone; Shi's ketone; borax; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; toluene-4-sulfonic acid;
In
toluene; acetonitrile;
DOI:10.1021/jo400648f
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / toluene / 3 h / 70 °C / Inert atmosphere
3: Na2B4O7*10H2O; tetra(n-butyl)ammonium hydrogensulfate; Shi's ketone; edetate disodium; oxone / acetonitrile; 1,2-dimethoxyethane / 4 h / -5 °C / Inert atmosphere
With
oxone; Shi's ketone; Na2B4O7*10H2O; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; toluene; acetonitrile;
3: |Shi Asymmetric Epoxidation;
DOI:10.1039/c3cc47550f
