(S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene

Base Information

Chemical Name:(S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene
CAS No.:1434533-55-7
Molecular Formula:C₁₈H₂₀OS
Molecular Weight:284.422
Hs Code.:

Synonyms:(S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene

Suppliers and Price of (S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene

There total 6 articles about (S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1434533-53-5
(S)-diphenyl(tetrahydrothiophen-2-yl)methanol

: 74-88-4
methyl iodide

: 1434533-55-7
(S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene

Guidance literature:: (S)-diphenyl(tetrahydrothiophen-2-yl)methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;
DOI:10.1021/jo400648f

Reference yield:

: 114736-31-1
5-bromo-1,1-diphenylpentan-1-ol

: 1434533-55-7
(S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 3 h / 70 °C

2.1: Shi's ketone; borax; tetra(n-butyl)ammonium hydrogensulfate; Oxone; potassium carbonate / acetonitrile / 4 h / -5 °C

3.1: sodiumsulfide nonahydrate / ethanol / 34 h / 10 - 25 °C / Sonication

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

4.2: 2 h / 20 °C

With Oxone; Shi's ketone; borax; sodiumsulfide nonahydrate; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1021/jo400648f

Reference yield:

: 2067-33-6
5-bromopentanoic acid

: 1434533-55-7
(S)-(+)-2-(methoxydiphenylmethyl)tetrahydrothiophene

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 2 h / Reflux

2.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 °C

2.2: 12 h / 0 - 20 °C

3.1: toluene-4-sulfonic acid / toluene / 3 h / 70 °C

4.1: Shi's ketone; borax; tetra(n-butyl)ammonium hydrogensulfate; Oxone; potassium carbonate / acetonitrile / 4 h / -5 °C

5.1: sodiumsulfide nonahydrate / ethanol / 34 h / 10 - 25 °C / Sonication

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

6.2: 2 h / 20 °C

With Oxone; thionyl chloride; Shi's ketone; borax; sodiumsulfide nonahydrate; iodine; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1021/jo400648f