(S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester

Base Information

• Chemical Name: (S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester
• CAS No.: 174152-11-5
• Molecular Formula: C₁₁H₁₂F₃NO₂
• Molecular Weight: 247.217
• Mol file: 174152-11-5.mol

Synonyms:(S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester

Chemical Property of (S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester

There total 5 articles about (S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.7%

(S)-methyl-2-(1,3-dioxoisoindolin-2-yl)-3-(4-(trifluoromethyl)phenyl)propanoate → (S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester (174152-11-5)

Guidance literature:

With ethylenediamine; In methanol; at 70 ℃; for 9h;

DOI:10.1016/j.bmc.2016.04.025

Reference yield: 58.0%

methanol (67-56-1) + (S)-4-trifluoromethylphenylalanine (3832-75-5,14091-16-8,114872-99-0,114926-38-4) → (S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester (174152-11-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 24h;

Reference yield:

4-Iodobenzotrifluoride (455-13-0) → (S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester (174152-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1: α-picoline; palladium diacetate; silver(I) acetate / 24 h / 20 - 75 °C / Sealed tube

2: [bis(acetoxy)iodo]benzene / 3 h / 80 °C

3: ethylenediamine / dichloromethane; methanol / 10 h / 20 - 40 °C

With α-picoline; [bis(acetoxy)iodo]benzene; silver(I) acetate; palladium diacetate; ethylenediamine; In methanol; dichloromethane;

DOI:10.1021/ja512690x

upstream raw materials:

methanol

(S)-4-trifluoromethylphenylalanine

4-Iodobenzotrifluoride

Downstream raw materials:

(S)-4-trifluoromethylphenylalanine

(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-(4-trifluoromethyl-phenyl)-propionic acid methyl ester

{(S)-1-[(S)-1-Carbamoyl-2-(4-trifluoromethyl-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

(S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-(4-hydroxyphenyl)propanamido)-3-(4-(trifluoromethyl)phenyl)propanoate