(5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one

Base Information

• Chemical Name: (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one
• CAS No.: 921599-50-0
• Molecular Formula: C₃₀H₃₉FN₄O₂
• Molecular Weight: 506.664
• Mol file: 921599-50-0.mol

Synonyms:(5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one

Chemical Property of (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one

There total 16 articles about (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one (921599-79-3) + 3-isopropoxybenzylchloride (26066-16-0) → (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one (921599-50-0)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 65 ℃;

DOI:10.1016/j.bmcl.2015.06.082

Reference yield:

C30H39FN4O2 → (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one (921599-50-0)

Guidance literature:

With diethylamine; In hexane; Isopropyl acetate; Resolution of racemate;

DOI:10.1016/j.bmcl.2015.06.082

Reference yield:

C30H39FN4O2 → (5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one (921599-50-0) + C30H39FN4O2

Guidance literature:

With ammonia; In methanol; hexane; chloroform; ethyl acetate; isopropyl alcohol; Purification / work up; Resolution of racemate;

upstream raw materials:

(5R,7S)-4-(cyclohexylamino)-1-(3-fluorophenyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one

3-isopropoxybenzylchloride

benzyl 2-methyl-4-oxopiperidine-1-carboxylate

benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate