4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole

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Chemical Name:4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole
CAS No.:1436611-81-2
Molecular Formula:C₂₃H₃₀N₄OS
Molecular Weight:410.583
Hs Code.:

Synonyms:4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole

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Chemical Property of 4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole

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Technology Process of 4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole

There total 12 articles about 4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1436613-47-6
4-phenyl-1-(p-tolylsulfonyl)-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazole

: 1436611-81-2
4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole

Guidance literature:: With potassium hydroxide; In methanol; for 0.5h; Reflux;

Reference yield:

: 4815-36-5
ethyl 2-amino-4-phenyl-thiophene-3-carboxylate

: 1436611-81-2
4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole

Guidance literature:: Multi-step reaction with 8 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0 - 20 °C

2: potassium hydroxide; water / ethanol / 3 h / 50 °C

3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

4: toluene / 2 h / 100 °C

5: thionyl chloride / 1 h / 80 °C

6: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 20 °C

7: copper(l) iodide; potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 180 °C / Microwave irradiation

8: potassium hydroxide / methanol / 0.5 h / Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; thionyl chloride; tert.-butylnitrite; water; potassium carbonate; N,N-dimethyl-formamide; potassium hydroxide; copper(ll) bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1248509-76-3
4-(2-pyrrolidin-1-ylethoxymethyl)piperidine

: 1436611-81-2
4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 20 °C

2: copper(l) iodide; potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 180 °C / Microwave irradiation

3: potassium hydroxide / methanol / 0.5 h / Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; potassium carbonate; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;