1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone

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Chemical Name:1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone
CAS No.:1436612-18-8
Molecular Formula:C₂₅H₃₂N₄O₂S
Molecular Weight:452.621
Hs Code.:

Synonyms:1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone

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Chemical Property of 1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone

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Technology Process of 1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone

There total 13 articles about 1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1436611-81-2
4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]-1H-thieno[2,3-c]pyrazole

: 75-36-5
acetyl chloride

: 1436612-18-8
1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1248509-76-3
4-(2-pyrrolidin-1-ylethoxymethyl)piperidine

: 1436612-18-8
1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 20 °C

2: copper(l) iodide; potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 180 °C / Microwave irradiation

3: potassium hydroxide / methanol / 0.5 h / Reflux

4: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;

Reference yield:

: 1436612-90-6
ethyl 2,5-dibromo-4-phenyl-thiophene-3-carboxylate

: 1436612-18-8
1-[4-phenyl-3-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-c]pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 8 steps

1: potassium hydroxide; water / ethanol / 3 h / 50 °C

2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

3: toluene / 2 h / 100 °C

4: thionyl chloride / 1 h / 80 °C

5: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 20 °C

6: copper(l) iodide; potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 180 °C / Microwave irradiation

7: potassium hydroxide / methanol / 0.5 h / Reflux

8: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; thionyl chloride; water; potassium carbonate; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; toluene;