3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester

Base Information

Chemical Name:3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester
CAS No.:959937-58-7
Molecular Formula:C₂₄H₃₁NO₆S
Molecular Weight:461.579
Hs Code.:

Synonyms:3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester

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Chemical Property of 3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester

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Technology Process of 3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester

There total 2 articles about 3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959937-60-1
(2S,5R)-5-(4-methoxy-benzyloxy)-1-(toluene-4-sulphonyl)piperidine-2-carbaldehyde

: 959937-58-7
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium tetrahydroborate / nickel dichloride / methanol / 1 h / 0 °C

With sodium tetrahydroborate; sodium hydride; nickel dichloride; In tetrahydrofuran; methanol;

Reference yield:

: 959937-61-2
[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]methanol

: 959937-58-7
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.75 h / -78 °C

1.2: 0.5 h / -78 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 1 h / 0 °C

3.1: sodium tetrahydroborate / nickel dichloride / methanol / 1 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 959937-58-7
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester

: 74-88-4
methyl iodide

: 959937-57-6
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

Guidance literature:: 3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-propionic acid methyl ester; With 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; at -78 ℃;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 1.5h;