4-[4-(4-ethoxycarbonylbutyl)phenyl]-4-oxo-butanoic acid

Base Information

• Chemical Name: 4-[4-(4-ethoxycarbonylbutyl)phenyl]-4-oxo-butanoic acid
• CAS No.: 6308-43-6
• Molecular Formula: C₁₇H₂₂O₅
• Molecular Weight: 306.359
• Hs Code.: 2918990090
• Mol file: 6308-43-6.mol

Synonyms:Valericacid, 5-[p-(3-carboxypropionyl)phenyl]-, 1-ethyl ester (8CI); Valeric acid,5-[p-(3-carboxypropionyl)phenyl]-, ethyl ester (6CI); NSC 42035

Chemical Property of 4-[4-(4-ethoxycarbonylbutyl)phenyl]-4-oxo-butanoic acid

Chemical Property:

• Vapor Pressure: 2.72E-10mmHg at 25°C
• Boiling Point: 486.9°C at 760 mmHg
• Flash Point: 174.1°C
• PSA: 80.67000
• Density: 1.145g/cm³
• LogP: 3.01000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[4-(4-ethoxycarbonylbutyl)phenyl]-4-oxo-butanoic acid

There total 1 articles about 4-[4-(4-ethoxycarbonylbutyl)phenyl]-4-oxo-butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid anhydride (108-30-5) + 5-Phenylpentanoic acid (2270-20-4) → 4-[4-(4-ethoxycarbonyl-butyl)-phenyl]-4-oxo-butyric acid (6308-43-6)

Guidance literature:

With aluminium trichloride;

DOI:10.1021/ja01545a050

Reference yield:

4-[4-(4-ethoxycarbonyl-butyl)-phenyl]-4-oxo-butyric acid (6308-43-6) → 5-[4-(3-carboxy-propyl)-phenyl]-valeric acid (94112-20-6)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; diethylene glycol;

DOI:10.1021/ja01545a050

Reference yield:

4-[4-(4-ethoxycarbonyl-butyl)-phenyl]-4-oxo-butyric acid (6308-43-6) → 5-[4-(3-methoxycarbonyl-propyl)-phenyl]-valeric acid methyl ester (101577-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N₂H₄+H₂O; KOH; diethylene glycol

2: H₂SO₄

With potassium hydroxide; sulfuric acid; hydrazine hydrate; diethylene glycol;

DOI:10.1021/ja01545a050

upstream raw materials:

succinic acid anhydride

5-Phenylpentanoic acid

Downstream raw materials:

5-[4-(3-carboxy-propyl)-phenyl]-valeric acid

<9>Paracyclophan

5-[4-(3-methoxycarbonyl-propyl)-phenyl]-valeric acid methyl ester

[9]paracyclophan-4-one