(4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine

Base Information

Chemical Name:(4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine
CAS No.:219136-58-0
Molecular Formula:C₂₄H₃₈O₄
Molecular Weight:390.563
Hs Code.:

Synonyms:(4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine

Chemical Property:

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Technology Process of (4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine

There total 1 articles about (4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 155095-85-5
2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-ethanol

: 219136-58-0
(4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 15h; Yield given; Ambient temperature;
DOI:10.1016/S0040-4039(98)02067-X

Reference yield: 92.0%

: 219136-58-0
(4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine

: 219136-91-1
(1S,2S,3S,4S)-3-(2-Benzyloxy-ethyl)-4-tert-butoxy-2-hydroxymethyl-3-methyl-cyclohexanol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1016/S0040-4039(98)02067-X

Reference yield:

: 219136-58-0
(4aS,5S,6S,8aS)-5-(2-Benzyloxy-ethyl)-6-tert-butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxine

: 219136-68-2
[2-(2-benzyloxy-ethyl)-3-tert-butoxy-2-methyl-6-methylene-cyclohexylmethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 5 percent aq. HCl / tetrahydrofuran / 4 h / Ambient temperature

2: DMAP / CH₂Cl₂ / 1.5 h / 0 - 20 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C

4: 50 percent / tetrahydrofuran / 0.67 h / Ambient temperature

With hydrogenchloride; dmap; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(99)00062-2