5-[(2,6-difluorobenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Chemical Name:5-[(2,6-difluorobenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine
CAS No.:1453207-63-0
Molecular Formula:C₂₈H₃₄F₂N₆O₂
Molecular Weight:524.614
Hs Code.:

Synonyms:5-[(2,6-difluorobenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Chemical Property of 5-[(2,6-difluorobenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Technology Process of 5-[(2,6-difluorobenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

There total 1 articles about 5-[(2,6-difluorobenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1254058-34-8
3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

: 4983-28-2
2-chloropyrimidine-5-ol

: 1453207-63-0
5-[(2,6-difluorobenzyl)oxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Guidance literature:: 2,6-Difluorobenzyl bromide; 2-chloropyrimidine-5-ol; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline; With palladium(II) acetate-2-(dicyclohexylphosphino)-2′,4′,6′-triisopropyl-1,1'-biphenyl; caesium carbonate; In tert-butyl alcohol; at 120 ℃; Inert atmosphere;