N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

Base Information

Chemical Name:N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester
CAS No.:1375483-23-0
Molecular Formula:C₃₂H₃₇N₃O₈S
Molecular Weight:623.727
Hs Code.:

Synonyms:N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

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Chemical Property of N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

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Technology Process of N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

There total 8 articles about N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: succinic acid mono-(2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl) ester

: 1001-53-2
monoacetylaminoethylamine

: 1375483-23-0
N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

Guidance literature:: succinic acid mono-(2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl) ester; With triethylamine; isobutyl chloroformate; In dichloromethane; for 0.75h; Cooling with ice; Inert atmosphere;

monoacetylaminoethylamine; In methanol; dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2012.02.044

Reference yield:

: 1375483-11-6
carbonic acid tert-butyl ester 2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-yl ester

: 1375483-23-0
N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere

3.1: piperidine / ethanol / 12 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / dichloromethane / 1 h

5.1: dmap / dichloromethane / 24 h / Reflux

6.1: triethylamine; isobutyl chloroformate / dichloromethane / 0.75 h / Cooling with ice; Inert atmosphere

6.2: 12 h / 20 °C

With piperidine; pyridine; dmap; potassium carbonate; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.02.044

Reference yield:

: 56305-04-5,53188-07-1
trolox

: 1375483-23-0
N-(2-acetylamino-ethyl)-succinamic acid 2-{4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-phenoxymethyl}-2,5,7,8-tetramethyl-chroman-6-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / 12 h / Reflux

2.1: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere

6.1: piperidine / ethanol / 12 h / Inert atmosphere; Reflux

7.1: trifluoroacetic acid / dichloromethane / 1 h

8.1: dmap / dichloromethane / 24 h / Reflux

9.1: triethylamine; isobutyl chloroformate / dichloromethane / 0.75 h / Cooling with ice; Inert atmosphere

9.2: 12 h / 20 °C

With piperidine; pyridine; dmap; lithium aluminium tetrahydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.02.044