1001-53-2Relevant articles and documents
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Haake,Watson
, p. 4063,4064 (1970)
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Synthesis and characterization of polyamidoamine dendrimers surface-functionalized with bromotricarbonylpyridyliminerhenium(I) units
Zhao, Xinxin,Yan, Yaw-Kai,Chu, Chit-Kay
, p. 5540 - 5546 (2006)
A novel type of rhenium-containing dendrimers has been prepared and characterized. A series of Schiff base-terminated PAMAM dendrimers were prepared by condensing the terminal amine groups of PAMAM dendrimers with pyridine-2-carboxaldehyde. Complete condensation of the terminal amines was confirmed by 1H NMR spectroscopy. Bromotricarbonylrhenium(I) moieties were introduced onto the surface of these modified PAMAM derivatives by refluxing with bromopentacarbonylrhenium(I). These complexes had been characterized by a variety of analytical and spectroscopic techniques and their IR, NMR, and mass spectra discussed. The crystal structure of the model compound [(CH3CONHCH2CH2N{double bond, long}CH{single bond}Py)ReBr(CO)3] confirms a facial configuration of the three carbonyl ligands. UV-Vis absorption spectroscopy suggests that the {Re(CO)3} moieties are quite far apart even in the second generation PAMAM dendrimers and do not interact with one another. In fact, the intensity of the metal-to-ligand (dπ-pπ*) charge-transfer is a linear function of the number of {Re(CO)3} chromophores.
Structural analysis of ATP analogues compatible with kinase-catalyzed labeling
Suwal, Sujit,Senevirathne, Chamara,Garre, Satish,Pflum, Mary Kay H.
, p. 2386 - 2391 (2012)
Kinase-catalyzed protein phosphorylation is an important biochemical process involved in cellular functions. We recently discovered that kinases promiscuously accept γ-modified ATP analogues as cosubstrates and used several ATP analogues as tools for stud
The mechanisms of the formation of by-products in the catalytic synthesis of C-alkylimidazoles from diamines and carboxylic acids
Gitis, K. M.,Raevskaya, N. I.,Isagulyants, G. V.
, p. 895 - 898 (1993)
The formation of 1-ethyl-2-methylimidazole (1-Et-2-MI) and 1-ethyl-2-methylimidazoline (1-Et-2-MIN), intermediates in the synthesis of 2-methylimidazole (2-MI) from ethylenediamine (EDA) and AcOH in the presence of a platinum-on-alumina catalyst, was studied.Using CH3(14)COOH the incorporation of two acetate units into 1-Et-2-MI and 1-Et-2-MIN molecules was demonstrated.The same products were also obtained on dehydrogenation of 2-methylimidazoline (2-MIN) under mild conditions (220-230 deg C).A part of the latter is transformed to N-ethyl ethylendiamine (EEDA) and EDA.These facts indicate that both 1-Et-2-MI and 1-Et-2-MIN result from hydrogenolysis of the imidazoline ring with subsequent ethylation.A reverse reaction, the C5-cyclization of EEDA, was also observed.The formation of 2-MI is favored by increasing temperature.
WDR5 INHIBITORS AND MODULATORS
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Paragraph 00326; 00327, (2021/05/15)
Isoquinolmone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times
Chapman, Michael R.,Kwan, Maria H. T.,King, Georgina,Jolley, Katherine E.,Hussain, Mariam,Hussain, Shahed,Salama, Ibrahim E.,González Nino, Carlos,Thompson, Lisa A.,Bayana, Mary E.,Clayton, Adam D.,Nguyen, Bao N.,Turner, Nicholas J.,Kapur, Nikil,Blacker, A. John
, p. 1294 - 1301 (2017/09/23)
A universal multistage cascade CSTR has been developed that is suitable for a wide range of continuous-flow processes. Coined by our group the "Freactor" (free-to-access reactor), the new reactor integrates the efficiency of pipe-flow processing with the advanced mixing of a CSTR, delivering a general "plug-and-play" reactor platform which is well-suited to multiphasic continuous-flow chemistry. Importantly, the reactor geometry is easily customized to accommodate reactions requiring long residence times (≥3 h tested).