2,3,4,6-Tetrachloroaniline

Base Information

• Chemical Name: 2,3,4,6-Tetrachloroaniline
• CAS No.: 654-36-4
• Molecular Formula: C6H3Cl4N
• Molecular Weight: 230.909
• UNII: 8RZO887M83
• DSSTox Substance ID: DTXSID10215709
• Nikkaji Number: J134.766G
• Wikidata: Q27270942
• Mol file: 654-36-4.mol

Synonyms:2,3,4,6-Tetrachloroaniline;654-36-4;2,3,4,6-Tetrachloro-phenylamine;Benzenamine, 2,3,4,6-tetrachloro-;UNII-8RZO887M83;8RZO887M83;2,3,4,6-Tetrachlorophenylamine;2,3,4,6-Tetrachloranilin;2,4,5,6-Tetrachloroaniline;SCHEMBL7289940;DTXSID10215709;MFCD24160457;AKOS026730760;AS-6351;ANILINE, 2,3,4,6-TETRACHLORO-;Q27270942

Chemical Property of 2,3,4,6-Tetrachloroaniline

Chemical Property:

• Vapor Pressure: 0.00124mmHg at 25°C
• Boiling Point: 298.8°C at 760 mmHg
• Flash Point: 134.5°C
• PSA: 26.02000
• Density: 1.655g/cm³
• LogP: 4.46360
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 230.899010
• Heavy Atom Count: 11
• Complexity: 143

Purity/Quality:

99% ^*data from raw suppliers

2,3,4,6-Tetrachlorophenylamine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(C(=C1Cl)Cl)Cl)N)Cl

Technology Process of 2,3,4,6-Tetrachloroaniline

There total 16 articles about 2,3,4,6-Tetrachloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

m,p-dichloroaniline (95-76-1) → 2,3,4,6-tetrachloroaniline (654-36-4)

Guidance literature:

With 1-chloro-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one; In N,N-dimethyl-formamide; at 20 ℃; for 12h; regioselective reaction;

DOI:10.1021/acs.orglett.6b00547

Reference yield:

2,3,4,5-tetrachloronitrobenzene (879-39-0) → 2,3,4,6-tetrachloroaniline (654-36-4)

Guidance literature:

With hydrogenchloride; tin; ethanol;

DOI:10.1042/bj0610611

Reference yield:

3-chloro-aniline (108-42-9) → 2,3,4,6-tetrachloroaniline (654-36-4)

Guidance literature:

With hydrogenchloride; acetic acid; Beim Chlorieren;

upstream raw materials:

2,5 dichloroaniline

2,3,4,6-tetrachloronitrobenzene

2,3,4,5-tetrachloronitrobenzene

nitrobenzene

Downstream raw materials:

1,2,3,5-tetrachlorobenzene

2,3,4,6-tetrachloroiodobenzene

2,2',3,3',4,4',6,6'-octachlorobiphenyl

2,3,4,6-Tetrachlorobiphenyl

Refernces

• 1、 BETTS,JAMES,THORPE. "The metabolism of pentachloronitrobenzene and". . p. 611 - 617. Retrieved 2007/10/13.