Technology Process of N-methyl-4-(4-(5-(3-methoxyphenyl)-1,3,4-thiadiazol-2-ylamino)phenoxy)picolinamide
There total 6 articles about N-methyl-4-(4-(5-(3-methoxyphenyl)-1,3,4-thiadiazol-2-ylamino)phenoxy)picolinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C22H21N5O4S;
With
sulfuric acid;
at 20 ℃;
for 0.5h;
Cooling with ice;
With
ammonia;
In
water;
DOI:10.3390/molecules16065130
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 17.5 h / 50 °C / Inert atmosphere; Reflux
2.1: tetrahydrofuran; methanol / 0 - 20 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C
3.2: 6 h / 80 °C / Inert atmosphere
4.1: sodium hydrogencarbonate / dichloromethane / 0.33 h / 0 °C
4.2: 5 h / 20 °C
5.1: ethanol / 1 h / 60 °C
6.1: sulfuric acid / 0.5 h / 20 °C / Cooling with ice
With
thionyl chloride; sulfuric acid; potassium tert-butylate; sodium hydrogencarbonate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules16065130
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; methanol / 0 - 20 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C
2.2: 6 h / 80 °C / Inert atmosphere
3.1: sodium hydrogencarbonate / dichloromethane / 0.33 h / 0 °C
3.2: 5 h / 20 °C
4.1: ethanol / 1 h / 60 °C
5.1: sulfuric acid / 0.5 h / 20 °C / Cooling with ice
With
sulfuric acid; potassium tert-butylate; sodium hydrogencarbonate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules16065130