1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

Base Information

Chemical Name:1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one
CAS No.:959460-49-2
Molecular Formula:C₃₆H₅₀N₆O₄
Molecular Weight:630.831
Hs Code.:

1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

Synonyms:1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

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Chemical Property of 1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

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Technology Process of 1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

There total 5 articles about 1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1-(5-amino-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

: 168539-99-9
tert-butyl (1-formylcyclopentyl)carbamate

: 959460-49-2
1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

Guidance literature:: 1-(5-amino-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one; tert-butyl (1-formylcyclopentyl)carbamate; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 766-05-2
cyclohexane carbonitrile

: 959460-49-2
1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron trichloride / toluene; xylene / 1 h / 0 - 20 °C

1.2: 0 - 20 °C / Heating / reflux

2.1: triethylamine / dichloromethane / 0.33 h / -40 °C

3.1: dichloromethane / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

5.2: 16 h / 90 °C

6.1: water; tin(ll) chloride / ethyl acetate / 16 h / Heating / reflux

6.2: 1 h

7.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 16 h / 20 °C

With water; boron trichloride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; tin(ll) chloride; In dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; xylene;

Reference yield:

: 108-44-1
1-amino-3-methylbenzene

: 959460-49-2
1-(5-((1-N-tert-butoxycarbonylamino-cyclopentylmethyl)-amino)-pyridin-2-yl)-5-cyclohexyl-8-methyl-3-(tetrahydro-pyran-4-yl)-1H-1,3,4-benzotriazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron trichloride / toluene; xylene / 1 h / 0 - 20 °C

1.2: 0 - 20 °C / Heating / reflux

2.1: triethylamine / dichloromethane / 0.33 h / -40 °C

3.1: dichloromethane / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

5.2: 16 h / 90 °C

6.1: water; tin(ll) chloride / ethyl acetate / 16 h / Heating / reflux

6.2: 1 h

7.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 16 h / 20 °C

With water; boron trichloride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; tin(ll) chloride; In dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; xylene;