2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide

Base Information

Chemical Name:2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide
CAS No.:1370347-25-3
Molecular Formula:C₁₅H₁₅Cl₂N₅O₄S
Molecular Weight:432.287
Hs Code.:

Synonyms:2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide

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Chemical Property of 2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide

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Technology Process of 2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide

There total 5 articles about 2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 901310-24-5
phenyl (4-methylpyrimidin-2-yl)carbamate

: 1370347-13-9
2-chloro-N-(4-chloro-3-sulfamoylphenyl)propanamide

: 1370347-25-3
2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;
DOI:10.1016/j.ejmech.2012.01.011

Reference yield:

: 946-30-5
2-chloro-5-nitrobenzenesulphonic acid sodium salt

: 1370347-25-3
2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 4 h / 5 - 130 °C

2: ammonia / water / 10 - 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 50 °C

4: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

With chlorosulfonic acid; palladium 10% on activated carbon; ammonia; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1016/j.ejmech.2012.01.011

Reference yield:

: 96-73-1
2-chloro-5-nitro-benzenesulfonic acid

: 1370347-25-3
2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / water / 1 h / 20 °C

2: chlorosulfonic acid / 4 h / 5 - 130 °C

3: ammonia / water / 10 - 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 50 °C

5: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

With chlorosulfonic acid; palladium 10% on activated carbon; ammonia; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1016/j.ejmech.2012.01.011