946-30-5

Basic information

• Product Name: Sodium 2-chloro-5-nitrobenzenesulfonate
• Synonyms: Benzenesulfonicacid, 2-chloro-5-nitro-, sodium salt (7CI,8CI,9CI);2-Chloro-5-nitrobenzenesulfonicacid sodium salt;6-Chloro-3-nitrobenzenesulfonic acid sodium salt;Sodium1-chloro-4-nitrobenzene-2-sulfonate;Sodium 6-chloro-3-nitrobenzenesulfonate
• CAS NO: 946-30-5
• Molecular Formula: C₆H₃ClNO₅S*Na
• Molecular Weight: 259.5995
• EINECS: 213-418-5
• Product Categories: Intermediates of Dyes and Pigments;Aromatics Compounds;Aromatics;Sulfur & Selenium Compounds;Phenyls & Phenyl-Het
• Mol File: 946-30-5.mol
• Article Data: 6

Chemical Properties

• Appearance: light-brown crystalline solid
• CAS DataBase Reference: Sodium 2-chloro-5-nitrobenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium 2-chloro-5-nitrobenzenesulfonate(946-30-5)
• EPA Substance Registry System: Sodium 2-chloro-5-nitrobenzenesulfonate(946-30-5)

Safety Data

• Hazardous Substances Data: 946-30-5(Hazardous Substances Data)

Usage

Description

Sodium 2-chloro-5-nitrobenzenesulfonate, also known as 2-chloro-5-nitrobenzene sodium sulfonate, is an organic compound with the chemical formula C6H3ClNNaO4S. It is a derivative of benzene with a chlorine atom at the 2nd position and a nitro group at the 5th position, attached to a sulfonate group. Sodium 2-chloro-5-nitrobenzenesulfonate is soluble in water and has a yellow crystalline appearance.

Uses

Used in Organic Synthesis:
Sodium 2-chloro-5-nitrobenzenesulfonate is used as a reagent in organic synthesis for the preparation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a versatile building block for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Research:
In the field of chemical research, Sodium 2-chloro-5-nitrobenzenesulfonate serves as a valuable compound for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity and functional groups make it an interesting subject for academic and industrial research, contributing to the advancement of organic chemistry.
Used in Dye and Pigment Industry:
Sodium 2-chloro-5-nitrobenzenesulfonate is used as an intermediate in the production of dyes and pigments. Its ability to form colored compounds makes it suitable for the synthesis of various dyes and pigments used in textiles, plastics, and other industries.
Used in Analytical Chemistry:
In analytical chemistry, Sodium 2-chloro-5-nitrobenzenesulfonate can be employed as a reagent for the detection and analysis of specific compounds. Its unique chemical properties can be utilized to develop analytical methods for the identification and quantification of various substances in complex samples.
Overall, Sodium 2-chloro-5-nitrobenzenesulfonate is a versatile compound with applications in various industries, including organic synthesis, chemical research, dye and pigment production, and analytical chemistry. Its unique structure and reactivity make it a valuable asset in the development of new compounds and technologies.

InChI:InChI=1/C6H4ClNO5S.Na/c7-5-2-1-4(8(9)10)3-6(5)14(11,12)13;/h1-3H,(H,11,12,13);/q;+1/p-1

Upstream product

• 96-73-1 2-chloro-5-nitro-benzenesulfonic acid 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 1370347-11-7 N-(4-chloro-3-sulfamoylphenyl)pivalamide 
• 1370347-12-8 N-(4-chloro-3-sulfamoylphenyl)acrylamide 
• 1370347-13-9 2-chloro-N-(4-chloro-3-sulfamoylphenyl)propanamide 
• 1370347-14-0 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoethyl acetate 
• 1370347-15-1 ethyl 2-(4-chloro-3-sulfamoylphenylamino)-2-oxoacetate 
• 1370347-16-2 N-(4-chloro-3-sulfamoylphenyl)-2,2,3,3,4,4,4-heptafluorobutanamide 
• 1370347-17-3 N-(4-chloro-3-sulfamoylphenyl)-2,2,2-trifluoroacetamide 
• 1370347-18-4 N-(4-chloro-3-sulfamoylphenyl)formamide 
• 1370347-19-5 N-(4-chloro-3-(N-(4-methylpyrimidin-2 ylcarbamoyl)sulfamoyl)phenyl)acetamide 
• 1370347-20-8 2-chloro-N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)acetamide 
• 1370347-21-9 N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)isobutyramide 
• 1370347-22-0 N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)cyclopropanecarboxamide 
• 1370347-23-1 N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)pivalamide 
• 1370347-24-2 N-(4-chloro-3-(N-(4-methylpyrimidin-2-ylcarbamoyl)sulfamoyl)phenyl)acrylamide 

Relevant articles and documents

Method for preparing sodium 3-nitrobenzene sulfonate and derivative thereof through chlorosulfonic acid sulfonation

The invention discloses a method for preparing sodium 3-nitrobenzene sulfonate and a derivative thereof through chlorosulfonic acid sulfonation. The method comprises the following steps: 1) putting anitrobenzene raw material and chlorosulfonic acid into a reaction container, heating to 90-150 DEG C, keeping the temperature, carrying out a sulfonation reaction, and discharging a hydrogen chloridegas generated in the reaction process outside the reaction system in time, wherein the mole ratio of the nitrobenzene raw material to the chlorosulfonic acid is 1:(0.4-0.6); 2) carrying out aftertreatment on the reaction liquid obtained in the step 1) by using soda, thereby obtaining the sodium 3-nitrobenzene sulfonate or the derivative thereof. By adopting the method, a reverse thinking mode is adopted, the amount of the chlorosulfonic acid is reduced till being smaller than that of the nitrobenzene, and then the small amount of the chlorosulfonic acid can be converted by using the excessiveamount of the nitrobenzene; therefore, the method disclosed by the invention has no problem of treating residual chlorosulfonic acid; in addition, the excessive nitrobenzene can be easily recycled andcirculated, the hydrogen chloride as a byproduct can be also easily separated and recycled.

Research on controllable degradation of sulfonylurea herbicides

In order to seek ecologically safer and environmentally benign sulfonylurea herbicides (SU), insight into the structure/bioassay/soil degradation tri-factor relationship was first established. With the introduction of various groups (alkyl, nitro, halogen, cyano etc.) at the 5th position of its benzene ring, structural derivatives of chlorsulfuron were designed, synthesized, and evaluated for their herbicidal activity. The structures of the title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR, mass spectrometry, elemental analysis and X-ray diffraction. Bioassay results confirmed that most derivatives retained their superior herbicidal activities in comparison with chlorsulfuron. After investigating the soil degradation behavior of each molecule under set conditions, it was found that structures with electron-withdrawing substituents at the 5th position of the benzene ring retained their long degradation half-lives, yet the introduction of electron-donating substituents accelerated the degradation rate. These results will provide a valuable clue to further explore the potential controllable degradation of SU and other herbicides, and to discover novel herbicides that are favorable for environmentally and ecologically sustainable development.

NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.