Chemical Property of Proglumide
Chemical Property:
- Appearance/Colour:White solid
- Vapor Pressure:9.33E-15mmHg at 25°C
- Melting Point:148-150°C
- Refractive Index:1.534
- Boiling Point:589.8 °C at 760 mmHg
- PKA:4.51±0.10(Predicted)
- Flash Point:310.5 °C
- PSA：86.71000
- Density:1.136 g/cm3
- LogP:2.68930
- Storage Temp.:Refrigerator
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- XLogP3:2.4
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:10
- Exact Mass:334.18925731
- Heavy Atom Count:24
- Complexity:413
- Purity/Quality:
-
99% *data from raw suppliers
Proglumide *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1
- Recent ClinicalTrials:Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis
- Recent EU Clinical Trials:A pivotal, multicentre, randomized, modified double-blind, placebo-controlled phase 3 trial to assess the safety and clinical efficacy of M-001, an influenza vaccine administered intramuscularly twice in older adults and the elderly (≥50 years of age).
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Description
Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.
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Uses
Anticholinergic.
