D-Proglumide

Base Information

Chemical Name:D-Proglumide
CAS No.:32999-90-9
Molecular Formula:C18H26 N2 O4
Molecular Weight:0
Hs Code.:
Mol file:32999-90-9.mol

Synonyms:Glutaramicacid, 4-benzamido-N,N-dipropyl-, D- (8CI); Pentanoic acid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (R)-; (-)-Proglumide; D-Proglumide

Suppliers and Price of D-Proglumide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of D-Proglumide

Chemical Property:

PSA：86.71000
LogP:2.68930

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of D-Proglumide

There total 13 articles about D-Proglumide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 98-88-4
benzoyl chloride

: 80982-01-0
(R)-4-Amino-4-dipropylcarbamoyl-butyric acid

: 32999-90-9,24485-90-3
5-dipropylamino-4(R)-benzamido-5-oxo-pentanoic acid

Guidance literature:: With sodium hydrogencarbonate; In diethyl ether; water; for 3h;
DOI:10.1248/cpb.36.3433

Reference yield:

: 6620-60-6,24485-90-3
proglumide

: 32999-84-1,24485-90-3
5-dipropylamino-4(S)-benzamido-5-oxo-pentanoic acid

: 32999-90-9,24485-90-3
5-dipropylamino-4(R)-benzamido-5-oxo-pentanoic acid

Guidance literature:: With MCCD-HPS packed column; In hydrogenchloride; acetonitrile; pH=8.6;
DOI:10.1021/ac0204909

Reference yield:

: 142-84-7
di-n-propylamine

: 32999-90-9,24485-90-3
5-dipropylamino-4(R)-benzamido-5-oxo-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NEt₃, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h

2: 1N NaOH / tetrahydrofuran / 2 h / Ambient temperature

3: 3.6 g / H₂ / palladium black / 3 h / Ambient temperature

4: 69 percent / NaHCO₃ / H₂O; diethyl ether / 3 h

With sodium hydroxide; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; palladium; In tetrahydrofuran; diethyl ether; water;
DOI:10.1248/cpb.36.3433