(4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one

Base Information

• Chemical Name: (4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one
• CAS No.: 619328-44-8
• Molecular Formula: C₁₉H₂₇NO₄
• Molecular Weight: 333.428

Synonyms:(4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one

Chemical Property of (4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one

There total 5 articles about (4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4S,2'S,3'S,5'S)-3-(7'-benzyloxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one (619328-34-6) → (4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one (619328-44-8)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethyl acetate; for 2h;

DOI:10.1039/b404205k

Reference yield:

(R)-2-methyl-1,4-butanediol 4-benzyl ether (96154-47-1) → (4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one (619328-44-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / NBS; PPh₃ / CH₂Cl₂ / 0.17 h / 20 °C

2: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 2 h

With N-Bromosuccinimide; hydrogen; triphenylphosphine; palladium dihydroxide; In dichloromethane; ethyl acetate;

DOI:10.1039/b404205k

Reference yield:

(2R)-4-benzyloxy-1-bromo-2-methylbutane (88409-08-9) → (4S,2'S,3'S,5'S)-3-(7'-hydroxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one (619328-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 2 h

With hydrogen; palladium dihydroxide; In ethyl acetate;

DOI:10.1039/b404205k

upstream raw materials:

(4S,2'S,3'S,5'S)-3-(7'-benzyloxy-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one

(R)-2-methyl-1,4-butanediol 4-benzyl ether

(2R)-4-benzyloxy-1-bromo-2-methylbutane

(1'S,2'S,2R)-4-benzyloxy-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-2,N-dimethylbutyramide

Downstream raw materials:

(+)-kalkitoxin

(4S,2'S,3'S,5'S)-3-(7'-methylamino-2',3',5'-trimethylheptanoyl)-4-phenyloxazolidin-2-one

(2R,3'S,5'S,6'S,4''S)-2,N-dimethyl-N-[3',5',6'-trimethyl-7'-oxo-7'-(2''-oxo-4''-phenyloxazolidin-3-yl)heptyl]butyramide

(1''R,2'R,3R,4S,6S)-3,4,6-trimethyl-8-[methyl-(2'-methylbutyryl)amino]octanoic acid (1''-benzylsulfanylmethylallyl)amide

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