5,7,8-TRIHYDROXYFLAVONE

Base Information

• Chemical Name: 5,7,8-TRIHYDROXYFLAVONE
• CAS No.: 4443-09-8
• Molecular Formula: C15H10O5
• Molecular Weight: 270.241
• Hs Code.: 2914400090
• Mol file: 4443-09-8.mol

Synonyms:2-Phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one;Norwogonin;FLAVONE,5,7,8-TRIHYDROXY;5,7,8-Trihydroxyflavone;5,7,8-trihydroxy-2-phenylchromen-4-one;5,7,8-Trihydroxy-2-phenyl-chromen-4-on;5,7,8-trihydroxy-2-phenyl-chromen-4-one;

Chemical Property of 5,7,8-TRIHYDROXYFLAVONE

Chemical Property:

• Vapor Pressure: 8.78E-12mmHg at 25°C
• Melting Point: 227-228 °C
• Boiling Point: 528.4°C at 760 mmHg
• PKA: 6.66±0.40(Predicted)
• Flash Point: 206°C
• PSA: 90.90000
• Density: 1.548g/cm³
• LogP: 2.57680

Purity/Quality:

≥98% ^*data from raw suppliers

Norwogonin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7,8-TRIHYDROXYFLAVONE

There total 27 articles about 5,7,8-TRIHYDROXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5,7-bis(benzyloxy)-8-hydroxy-2-phenyl-4H-chromen-4-one → norwogonin (4443-09-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Reagent/catalyst;

DOI:10.1016/j.tetlet.2016.06.085

Reference yield: 95.0%

5,8-dihydroxy-7-methoxyflavone (4431-47-4) → norwogonin (4443-09-8)

Guidance literature:

With boron tribromide; In dichloromethane; at -15 - 20 ℃; for 12h;

Reference yield: 50.0%

5,7-dihydroxy-2-phenyl-chromen-4-one (480-40-0) → norwogonin (4443-09-8)

Guidance literature:

5,7-dihydroxy-2-phenyl-chromen-4-one; With dipotassium peroxodisulfate; potassium hydroxide; In water; at 0 - 20 ℃; for 2h;

With hydrogenchloride; sodium sulfite; In water; at 90 ℃; for 2h;

DOI:10.1080/09168451.2017.1303362

upstream raw materials:

5,7-dihydroxy-2-phenyl-chromen-4-one

1-phenyl-3-(2,3,4,6-tetramethoxy-phenyl)-propane-1,3-dione

wogonin

7-hydroxy-5,8-dimethoxyflavone

Downstream raw materials:

5-hydroxy-7,8-dimethoxyflavone

5-hydroxy-7,8-dimethoxy-6-methyl-2-phenyl-chromen-4-one

7,8-diacetoxy-5-hydroxy-2-phenyl-chromen-4-one

5,7,8-triacetoxy-2-phenyl-chromen-4-one