tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester

Base Information

Chemical Name:tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester
CAS No.:222165-65-3
Molecular Formula:C₆₄H₈₉N₃O₁₃
Molecular Weight:1108.42
Hs Code.:

tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester

Synonyms:tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester

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Chemical Property of tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester

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Technology Process of tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester

There total 3 articles about tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 4530-20-5
BOC-glycine

: 203795-56-6
24-triphenylmethoxy-5β-cholan-3α,7α,12α-triol

: 222165-65-3
tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0040-4039(99)00075-1

Reference yield:

: 1448-36-8
methyl cholate

: 222165-65-3
tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / Reflux

2: dmap; triethylamine / N,N-dimethyl-formamide / 30 h / 50 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide

With dmap; lithium aluminium tetrahydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 3758-71-2
3α,7α,12α-trihydroxycholan-24-ol

: 222165-65-3
tert-Butoxycarbonylamino-acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7-bis-(2-tert-butoxycarbonylamino-acetoxy)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-12-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / N,N-dimethyl-formamide / 30 h / 50 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide

With dmap; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;