(1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester

Base Information

Chemical Name:(1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester
CAS No.:180322-85-4
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:

Synonyms:(1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester

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Chemical Property of (1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of (1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester

There total 5 articles about (1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: C₂₁H₂₉NO₆

: 180322-85-4
(1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1002/1521-3773(20010417)40:8<1433::AID-ANIE1433>3.0.CO;2-E

Reference yield:

: 27992-27-4,40154-38-9
sodium 2-benzylidene-1-tosylhydrazin-1-ide

: 180322-85-4
(1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: C₁₆H₂₄OS (chiral); Rh₂(OAc)4; BnEt₃N⁽¹⁺⁾*Cl^(1-) / dioxane / 40 °C

2: 46 percent / TFA; Et₃SiH / CH₂Cl₂ / 2 h / 0 °C

With triethylsilane; dirhodium tetraacetate; C₁₆H₂₄OS (chiral); N-benzyl-N,N,N-triethylammonium chloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1002/1521-3773(20010417)40:8<1433::AID-ANIE1433>3.0.CO;2-E

Reference yield:

: 201338-62-7
N,N-tert-butoxycarbonyldehydroalanine

: 180322-85-4
(1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: C₁₆H₂₄OS (chiral); Rh₂(OAc)4; BnEt₃N⁽¹⁺⁾*Cl^(1-) / dioxane / 40 °C

2: 46 percent / TFA; Et₃SiH / CH₂Cl₂ / 2 h / 0 °C

With triethylsilane; dirhodium tetraacetate; C₁₆H₂₄OS (chiral); N-benzyl-N,N,N-triethylammonium chloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1002/1521-3773(20010417)40:8<1433::AID-ANIE1433>3.0.CO;2-E