Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-cis)- (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-cis)- (9CI)
• CAS No.: 110769-84-1
• Molecular Formula: C11H13 N O2
• Molecular Weight: 191.23
• Hs Code.: 2922499990
• Mol file: 110769-84-1.mol

Synonyms:Methyl(1R,2R)-1-amino-2-phenylcyclopropanecarboxylate

Chemical Property of Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-cis)- (9CI)

Chemical Property:

• PSA: 52.32000
• LogP: 1.74470

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-cis)- (9CI)

There total 16 articles about Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, methyl ester, (1R-cis)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

methyl 1-benzamido-2-phenyl-cyclopropanecarboxylate (70315-54-7,82112-02-5,82112-03-6,87378-71-0,87378-72-1) → (Z)-2,3-methanophenylalanine methyl ester (110769-86-3,123039-88-3,197778-15-7) + methyl (1R,2R)-1-amino-2-phenylcyclopropanecarboxylate (110769-84-1,123039-88-3,197778-15-7)

Guidance literature:

methyl 1-benzamido-2-phenyl-cyclopropanecarboxylate; With triethyloxonium fluoroborate; In dichloromethane;

With hydrogenchloride; In diethyl ether;

DOI:10.1016/j.bmcl.2009.07.114

Reference yield:

methyl cis-1-amino-2-(4-bromophenyl)cyclopropanecarboxylate hydrochloride → (Z)-2,3-methanophenylalanine methyl ester (110769-86-3,123039-88-3,197778-15-7) + methyl (1R,2R)-1-amino-2-phenylcyclopropanecarboxylate (110769-84-1,123039-88-3,197778-15-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 48h; under 3750.38 Torr;

Reference yield:

methyl (1S,2S)-1-nitro-2-phenylcyclopropanecarboxylate (1095278-82-2) → C11H13NO2 (1379337-81-1,123039-88-3,197778-15-7) + (Z)-2,3-methanophenylalanine methyl ester (110769-86-3,123039-88-3,197778-15-7) + methyl (1R,2R)-1-amino-2-phenylcyclopropanecarboxylate (110769-84-1,123039-88-3,197778-15-7)

Guidance literature:

methyl (1S,2S)-1-nitro-2-phenylcyclopropanecarboxylate; With hydrogenchloride; zinc; In water; isopropyl alcohol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; isopropyl alcohol; for 0.333333h; Saturated solution;

DOI:10.1016/j.tet.2011.05.113

upstream raw materials:

monomethyl (1S,2R)-2-phenylcyclopropane-1,1-dicarboxylate

methyl 1-benzamido-2-phenyl-cyclopropanecarboxylate

methyl (1S,2R)-1-nitro-2-phenylcyclopropanecarboxylate

styrene

Downstream raw materials:

(1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid methyl ester

1α-amino-2α-phenyl-1β-cyclopropanecarboxylic acid hydrochloride

(1R,2R)-1-tert-Butoxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid