N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide
CAS No.:509093-91-8
Molecular Formula:C₂₈H₃₃F₃N₄O₂
Molecular Weight:514.591
Hs Code.:

Synonyms:N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

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Chemical Property of N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

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Technology Process of N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

There total 11 articles about N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: ethyl (1s,4s)-4-(5-(piperidin-1-ylmethyl)-2-(3-(trifluoromethyl)benzamido)-1H-benzo[d]imidazol-1-yl)cyclohexane-1-carboxylate

: 509093-91-8
N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2015.10.060

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 509093-91-8
N-(1-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

2: N-ethyl-N,N-diisopropylamine / 110 °C

3: tin(II) chloride dihdyrate / ethanol; ethyl acetate / 100 °C

4: acetonitrile; methanol; water / 100 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide

6: diisobutylaluminium hydride / toluene; tetrahydrofuran

With 4-methyl-morpholine; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2015.10.060