2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine

Base Information

Chemical Name:2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine
CAS No.:1437126-73-2
Molecular Formula:C₂₁H₃₁F₂N₅O₆Si
Molecular Weight:515.589
Hs Code.:

Synonyms:2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine

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Chemical Property of 2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine

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Technology Process of 2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine

There total 3 articles about 2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1437125-07-9
2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(3-(difluoromethoxy)benzyl)amino)ethanol

: 5213-49-0
2,4-dinitro-1H-imidazole

: 1437126-73-2
2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine

Guidance literature:: 2,4-dinitro-1H-imidazole; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 0.583333h; Inert atmosphere;

2-((2-((tert-butyldimethylsilyl)oxy)ethyl)(3-(difluoromethoxy)benzyl)amino)ethanol; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 85684-61-3
3-(difluoromethoxy)-benzaldehyde

: 1437126-73-2
2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 2 h / 20 °C

1.2: 0.5 h

1.3: 18 h / 0 - 20 °C

2.1: potassium carbonate / acetonitrile / Reflux

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1437126-73-2
2-((tert-butyldimethylsilyl)oxy)-N-(3-(difluoromethoxy)benzyl)-N-(2-(2,4-dinitro-1H-imidazol-1-yl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 20 °C

2.1: potassium carbonate / acetonitrile / Reflux

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;