85684-61-3

Basic information

• Product Name: 3-(Difluoromethoxy)benzaldehyde
• Synonyms: 3-(DIFLUOROMETHOXY)BENZALDEHYDE;3-(Difluoromethoxy)benzaldehyde 98%;3-(Difluoromethoxy)benzaldehyde98%;1-(Difluoromethoxy)-3-formylbenzene;Benzaldehyde,3-(difluoroMethoxy)-
• CAS NO: 85684-61-3
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• Product Categories: Benzaldehyde;Fluorine series
• Mol File: 85684-61-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 80-90°C/0.3mm
• Flash Point: 107 °C
• Appearance: /
• Density: 1.300
• Vapor Pressure: 0.0838mmHg at 25°C
• Refractive Index: n20/D 1.496(lit.)
• Storage Temp.: Room temperature.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-(Difluoromethoxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Difluoromethoxy)benzaldehyde(85684-61-3)
• EPA Substance Registry System: 3-(Difluoromethoxy)benzaldehyde(85684-61-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 85684-61-3(Hazardous Substances Data)

Usage

General Description

3-(Difluoromethoxy)benzaldehyde is a chemical compound with the molecular formula C8H6F2O2. It is a benzaldehyde derivative with two fluorine atoms attached to the methoxy group. 3-(Difluoromethoxy)benzaldehyde is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable intermediate for the production of specialty chemicals, especially in the pharmaceutical industry. Additionally, it is also used as a building block in the synthesis of fluorinated organic compounds and as a reagent in chemical reactions. Overall, 3-(Difluoromethoxy)benzaldehyde plays a vital role in the development of diverse chemical applications and holds significance in the field of organic chemistry.

InChI:InChI=1/C8H6F2O2/c9-8(10)12-7-3-1-2-6(4-7)5-11/h1-5,8H

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 1895-39-2 sodium chlorodifluoroacetate 
• 188554-13-4 2-hydroxypyridine-4-carboxaldehyde 
• 620-24-6 3-Hydroxybenzyl alcohol 
• 125903-81-3 (3-(difluoromethoxy)phenyl)methanol 

Downstream Products

• 1268516-11-5 (2-(difluoromethoxy)pyridin-4-yl)methanol 
• 1622219-88-8 (3-(difluoromethoxy)phenyl)(2-(3,5-difluorophenyl)-1,3-dithian-2-yl)methanol 
• 1622219-89-9 2-(3-(difluoromethoxy)phenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone 
• 1622219-90-2 1-(3-(difluoromethoxy)phenyl)-2-(3,5-difluorophenyl)ethane-1,2-dione 
• 1622219-58-2 2-amino-4-(3-(difluoromethoxy)phenyl)-4-(3,5-difluorophenyl)-1-methyl-1H-imidazol-5(4H)-one 
• 910034-86-5 1-(difluoromethoxy)-3-vinylbenzene 

Relevant articles and documents

Difluoromethylation of Phenols and Thiophenols with the S-(Difluo-romethyl)sulfonium Salt: Reaction, Scope, and Mechanistic Study

A facile and practical approach for the difluoromethylation of phenols and thiophenols was described. Making use of the recently developed bench-stable S-(difluoromethyl)sulfonium salt as the difluorocarbene precursor, a wide variety of diversely functionalized phenols and thiophenols were readily converted to their corresponding aryl difluoromethyl ethers in good to excellent yields in the presence of lithium hydroxide. Chemoselectivity of various O,S-nucleophiles toward difluorocarbene was systematically studied, suggesting the reactivity order ArS- > RS-, ArO- > ROH > RO-, ArSH, ArOH, RSH.

HETEROCYCLIC FUSED PHENANTHROLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to heterocyclic fused phenanthrolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

5-substituted[1,2,4]triazolo[1,5-c]pyrimidin-2-amines

This invention is concerned with 5-substituted[1,2,4]triazolo[1,5-c]pyrimidin-2-amines selected from those of Formula I, which are active as antiasthma agents.