((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine

Base Information

• Chemical Name: ((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine
• CAS No.: 410083-28-2
• Molecular Formula: C₁₉H₂₂N₂O
• Molecular Weight: 294.396
• Mol file: 410083-28-2.mol

Synonyms:((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine

Chemical Property of ((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine

There total 3 articles about ((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-1-phenyl-ethylamine (2627-86-3) + pyridin-3-yl-(tetrahydro-pyran-4-yl)-methanone (410083-27-1) → ((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine (410083-28-2)

Guidance literature:

With titanium tetrachloride; triethylamine; In dichloromethane; at 0 - 25 ℃; for 12h;

DOI:10.1016/S0040-4039(01)01985-2

Reference yield:

tetrahydro-2H-pyran-4-carbonylchloride (40191-32-0) → ((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine (410083-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)PhCH2]Pd(II)2 / xylene / 0.5 h / 120 °C

2: 83 percent / Et₃N; TiCl₄ / CH₂Cl₂ / 12 h / 0 - 25 °C

With titanium tetrachloride; triethylamine; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); In dichloromethane; xylene; 1: Stille coupling;

DOI:10.1016/S0040-4039(01)01985-2

Reference yield:

3-(tributylstannyl)pyridine (59020-10-9) → ((S)-1-Phenyl-ethyl)-[1-pyridin-3-yl-1-(tetrahydro-pyran-4-yl)-meth-(Z)-ylidene]-amine (410083-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)PhCH2]Pd(II)2 / xylene / 0.5 h / 120 °C

2: 83 percent / Et₃N; TiCl₄ / CH₂Cl₂ / 12 h / 0 - 25 °C

With titanium tetrachloride; triethylamine; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); In dichloromethane; xylene; 1: Stille coupling;

DOI:10.1016/S0040-4039(01)01985-2

upstream raw materials:

(S)-1-phenyl-ethylamine

pyridin-3-yl-(tetrahydro-pyran-4-yl)-methanone

tetrahydro-2H-pyran-4-carbonylchloride

3-(tributylstannyl)pyridine

Downstream raw materials:

((S)-1-Phenyl-ethyl)-[(S)-pyridin-3-yl-(tetrahydro-pyran-4-yl)-methyl]-amine