(3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate

Base Information

Chemical Name:(3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate
CAS No.:862248-96-2
Molecular Formula:C₃₅H₃₆N₂O₇
Molecular Weight:596.68
Hs Code.:

Synonyms:(3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate

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Chemical Property of (3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate

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Technology Process of (3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate

There total 1 articles about (3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 777088-07-0
(R)-benzyl 4-(3-acryloyloxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)-benzoate

: 65899-49-2
1(E)-<(benzyloxycarbonyl)amino>-1,3-butadiene

: 862248-96-2
(3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate

: 862248-97-3
(3'R,1S,2R)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate

Guidance literature:: In toluene; at 60 ℃; for 24h;
DOI:10.1016/j.tetasy.2005.05.024

Reference yield: 43.0%

: 862248-96-2
(3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate

: 777087-96-4
(R)-4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl) benzoic acid

: (1R,2S)-2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 5h;
DOI:10.1016/j.tetasy.2005.05.024

Reference yield:

: 862248-96-2
(3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate

: (1R,2S)-1-benzylcarbamoyl-2-(benzyloxycarbonylamino)cyclohex-3-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 5 h / 20 °C

2: 94 percent / 2-chloro-1-methyl pyridinium iodide; triethylamine / CH₂Cl₂

With lithium hydroxide; 2-chloro-1-methyl-pyridinium iodide; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetasy.2005.05.024