777088-07-0

Upstream product

• 737762-29-7 (+/-)-benzyl 4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoate 
• 777087-93-1 (1S,3'R)-[1-(4-benzyloxycarbonylphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] 4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylate 
• 777087-95-3 (R)-benzyl 4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoate 
• 814-68-6 acryloyl chloride 

Downstream Products

• 777087-96-4 (R)-4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl) benzoic acid 
• 1030359-46-6 (3'R,1R,4R,7R)-1-[4-(benzyloxycarbonyl)phenyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl 2-(benzyloxycarbonyl)-2-azabicyclo[2.2.2]oct-5-ene-7-carboxylate 
• 1030359-48-8 (3'R,1S,4S,7S)-1-[4-(benzyloxycarbonyl)phenyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl 2-(benzyloxycarbonyl)-2-azabicyclo[2.2.2]oct-5-ene-7-carboxylate 
• 1030359-47-7 (3'R,1R,4R,7S)-1-[4-(benzyloxycarbonyl)phenyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl 2-(benzyloxycarbonyl)-2-azabicyclo[2.2.2]oct-5-ene-7-carboxylate 
• 862248-96-2 (3'R,1R,2S)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate 
• 862248-97-3 (3'R,1S,2R)-N-(4'-benzyloxycarbonylphenyl)-4',4'-dimethyl-2'-oxopyrrolidin-3'-yl 2-(benzyloxycarbonylamino)cyclohex-3-ene-1-carboxylate 

Relevant academic research and scientific papers

Asymmetric Diels-Alder reaction using a new chiral β-nitroacrylate for enantiopure trans-β-norbornane amino acid preparation

The main nitronorbornene adduct derived from the asymmetric Diels-Alder reaction of (S)-benzyl-4-(3-(3-nitroacryloyloxy)-4,4-dimethyl-2-oxopyrrolidin-1-yl)b enzoate (S)-1 and cyclopentadiene was isolated and transformed to afford the enantiopure bicyclic

(R)- or (S)-4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoic acid as a new chiral auxiliary for solid phase asymmetric Diels-Alder reactions

The synthesis of enantiopure (R)- and (S)-4-(3-hydroxy-4,4-dimethyl-2- oxopyrrolidin-1-yl)benzoic acid is described and the corresponding supported chiral acrylate derivative has been used as a dienophile in solid phase asymmetric Diels-Alder reactions wi