N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1078709-27-9
Molecular Formula:C₁₉H₂₄ClN₃O₃
Molecular Weight:377.871
Hs Code.:

Synonyms:N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide

There total 6 articles about N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1078709-26-8
3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxylic acid

: 39895-55-1
4-(1,1-dimethylethyl)-benzenemethanamine

: 1078709-27-9
N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: 3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; Inert atmosphere;

4-(1,1-dimethylethyl)-benzenemethanamine; With dmap; triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo801729p

Reference yield:

: 36983-35-4
ethyl 4-(furan-2-yl)-2,4-dioxobutyrate

: 1078709-27-9
N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2,2-trifluoroethanol / 1 h

2: sodium periodate; ruthenium(III) chloride trihydrate / ethyl acetate; water / 2 h

3: sodium hypochlorite / acetic acid / 10 - 12 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / acetonitrile

5: triethylamine; dmap

With dmap; sodium hypochlorite; sodium periodate; oxalyl dichloride; ruthenium(III) chloride trihydrate; triethylamine; N,N-dimethyl-formamide; In 2,2,2-trifluoroethanol; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1021/op500114v

Reference yield:

: 104296-35-7
3-(ethoxycarbonyl)-5-(2-furyl)-1-methylpyrazole

: 1078709-27-9
N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate; ruthenium(III) chloride trihydrate / ethyl acetate; water / 2 h

2: sodium hypochlorite / acetic acid / 10 - 12 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / acetonitrile

4: triethylamine; dmap

With dmap; sodium hypochlorite; sodium periodate; oxalyl dichloride; ruthenium(III) chloride trihydrate; triethylamine; N,N-dimethyl-formamide; In water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1021/op500114v