N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1078709-28-0
Molecular Formula:C₁₇H₂₀ClN₃O₂
Molecular Weight:333.818
Hs Code.:

Synonyms:N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide

There total 7 articles about N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: C₁₇H₂₂ClN₃O₂

: 1078709-28-0
N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -60 - 0 ℃; for 1h;
DOI:10.1021/op500114v

Reference yield:

: 36983-35-4
ethyl 4-(furan-2-yl)-2,4-dioxobutyrate

: 1078709-28-0
N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 2,2,2-trifluoroethanol / 1 h

2: sodium periodate; ruthenium(III) chloride trihydrate / ethyl acetate; water / 2 h

3: sodium hypochlorite / acetic acid / 10 - 12 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / acetonitrile

5: triethylamine; dmap

6: lithium borohydride / tetrahydrofuran / 2 h / 65 °C

7: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -60 - 0 °C

With dmap; sodium hypochlorite; sodium periodate; lithium borohydride; oxalyl dichloride; ruthenium(III) chloride trihydrate; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; water; acetic acid; ethyl acetate; acetonitrile; 7: |Swern Oxidation;
DOI:10.1021/op500114v

Reference yield:

: C₈H₈Cl₂N₂O₃

: 1078709-28-0
N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dmap

2: lithium borohydride / tetrahydrofuran / 2 h / 65 °C

3: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -60 - 0 °C

With dmap; lithium borohydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 3: |Swern Oxidation;
DOI:10.1021/op500114v